ea0009oc6 | Oral Communication 1: Diabetes and metabolism | BES2005
Pritchard L
, Creemers J
, Gyte A
, Davies N
, Le Rouzic P
, Lawrence C
, Luckman S
, Brennand J
, White A
Agouti-related protein (AGRP) plays a key role in energy homeostasis with the carboxy-terminal domain acting as an endogenous antagonist of the melanocortin-4 receptor (MC4-R). It has been suggested that the amino-terminal domain of AGRP binds to syndecan-3, allowing it to regulate local concentrations of AGRP at the MC4-R. This model assumes that AGRP is secreted as a full-length peptide. However, AGRP contains several consensus prohormone convertase cleavage sites: Lys52-Lys...